Reduced Leukocyte Infiltration in Absence of Eosinophils Correlates with Decreased Tissue Damage and Disease Susceptibility in ΔdblGATA Mice during Murine Neurocysticercosis
Fig 5
Increased T cell infiltration in ΔdblGATA mice.
Brain tissues from WT (A) and ΔdblGATA mice (B) at 2 wks p.i were stained with anti-TCRβ antibodies. Percent of total infiltrates (C) and total cell numbers (D) assessment of αβ T cells based on IF staining of cytospun brain infiltrates revealed an increased T cell infiltration in ΔdblGATA mice brains. Flow cytometry analysis of brain infiltrates of WT (E) and ΔdblGATA mice (F) also revealed an increased frequency and overall numbers of T cells (G, H) in eosinophil-deficient mice. Further assessment of CD4 and CD8 subpopulation (I, J) by flow cytometry showed an increased frequency and number of CD8 T cell in ΔdblGATA mice (filled bars) when compared to WT mice (open bars).