Human IgG1 Responses to Surface Localised Schistosoma mansoni Ly6 Family Members Drop following Praziquantel Treatment
Fig 1
SmLy6 members demonstrate feature conservation characteristic of the uPAR/Ly6 superfamily.
PSI-BLAST querying was used to identify eleven Ly6 family members in the S. mansoni genome (v 5.0). A) Diagrammatic representation of protein features characteristic of a single domain Ly6 protein. B) MUSCLE alignment of the deduced full-length amino acid sequences of SmLy6A—K sequences (SmLy6D sequence is split into SmLy6D 1st and 2nd domains). Predicted signal peptide sequences are highlighted in red. Conserved cysteines are shaded in yellow and labelled C1 to C10. Predicted GPI anchor sites are shaded in green and hydrophobic regions are highlighted in blue. The four amino acids shown to be essential in HsCD59 function [47] are indicated on the sequence by boxes. The amino acid numbering (indicated at left of alignment) begins at the initiating M of each protein.