Pharmacokinetics of Naja sumatrana (Equatorial Spitting Cobra) Venom and Its Major Toxins in Experimentally Envenomed Rabbits
Figure 1
Serum concentration-time profile of N. sumatrana venom following intravenous and intramuscular injection of the venom.
Rabbits (approximately 2 kg) were injected intravenously (i.v.) and intramuscularly (i.m.) with a sub-lethal dose of N. sumatrana venom. The dose for intravenous injection (dotted line) was 0.1 mg/kg and for intramuscular injection (solid line), 0.5 mg/kg. The serum venom antigen concentrations were determined by double-sandwich ELISA (in semi-logarithmic plot) and given as the means ± S.D. (n = 3). The insert shows the serum concentration-time profile of N. sumatrana venom following intramuscular injection of venom (in arithmetic plot) during the first 3 h.