Efficacy of Cyclooctadepsipeptides and Aminophenylamidines against Larval, Immature and Mature Adult Stages of a Parasitologically Characterized Trichurosis Model in Mice
Figure 5
In vivo dose-response curves of emodepside (red) and PF1022A (blue) after oral (A), intraperitoneal (B) or subcutaneous (C) treatments against mature adults of T. muris.
Dose-response curves show the arithmetic mean values with standard errors of the mean with a group size of five animals per drug and dose. Efficacy was calculated as relative number of recovered worms compared to the no-drug control in percentage. Dosages were log10 transformed and logistic regressions were calculated with top values constrained between 0 and 100%. Triangles indicate a single dose of PF1022A (light blue), circles three doses of PF1022A (dark blue) and squares three doses of emodepside (red). Efficacies were set to zero if mean of the worm counts was higher than the mean of the corresponding control group. Furthermore, the corresponding SEM values of the affected groups start from zero. The no-drug controls were set to 10−4 mg/kg to allow log10 transformation of dosages.