Correlation between Dengue-Specific Neutralizing Antibodies and Serum Avidity in Primary and Secondary Dengue Virus 3 Natural Infections in Humans
Figure 1
Longitudinal analysis of DENV-specific serum neutralizing Abs.
A. DENV3-specific NT50 of serum day 4–6 (acute), day 14–28 (convalescent), 3 m, 6 m and 18 m post-onset of symptoms in 1° DENV3 infections. Longitudinal serum samples were analyzed via a flow cytometry-based neutralization assay. The mean +/− SD as well as the 25th and 75th percentiles of NT50 are displayed. B. DENV3-specific NT50 of serum day 6 (acute), day 14–28 (convalescent), 3 m, 6 m and 18 m post-onset of symptoms in 2° DENV3 infections. Longitudinal serum samples were analyzed as described in Figure 1A. C. DENV2-specific NT50 of serum day 6 (acute), day 14–28 (convalescent), 3 m, 6 m and 18 m post-onset of symptoms in 2° DENV3 infections. Longitudinal serum samples were analyzed as described in Figure 1A. Diamonds, mean; middle line, median; upper and lower boundary of the box, intra-quartile range (IQR; 25th to 75th percentile); whiskers, range of values that are outside of the IQR but are close enough not to be considered outliers (within ≤1.5*IQR); empty circles: outliers >1.5*IQR.