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Microbial Translocation Is Associated with Extensive Immune Activation in Dengue Virus Infected Patients with Severe Disease

Figure 5

Heatmap of cluster analysis.

A cluster analysis was performed with 23 cytokines, which resulted in a dendrogram indicated on the left of the heatmap. Every horizontal line indicates one patients. The vertical bar on the left of the heatmap indicates the disease severity of the patient. A: Cluster with mainly healthy controls and four dengue patients. B: Cluster with mild to moderately ill dengue virus infected patients. C: Cluster with severely ill dengue virus infected patients. Abbreviations: 1: non-severe dengue without warning signs. 2: non-severe dengue with warning signs. 3: severe dengue. +: patient died within 14 days after the onset of fever.

Figure 5

doi: https://doi.org/10.1371/journal.pntd.0002236.g005