Isothermal Microcalorimetry, a New Tool to Monitor Drug Action against Trypanosoma brucei and Plasmodium falciparum
Figure 4
Calorimetric measurements of P. falciparum exposed to different drugs.
Heat flow curves of P. falciparum in culture with 5% hematocrit and an initial parasitemia of 0.5% without drugs (blue) or with drugs at two different concentrations. Control measurements were performed with samples containing uninfected erythrocytes only (black). All measurements were performed in triplicate. A: summary, all three compounds at 3× IC50 and 10× IC50; B: Dihydroartemisinin at 3× IC50 (magenta) and 10× IC50 (red). C: Chloroquine at 3× IC50 (light violet) and 10× IC50 (dark violet); D: Artemether at 3× IC50 (light green) and 10× IC50 (dark green).