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Differential Gene Repertoire in Mycobacterium ulcerans Identifies Candidate Genes for Patho-Adaptation

Figure 2

Description of RDs1-15 throughout the M. ulcerans haplotypes.

Shown are the CDSs of the M. marinum M sequence backbone (which is closest to the entirety of all M. ulcerans haplotypes and thus to an M. ulcerans most recent common ancestor). Variations thereof in M. ulcerans haplotypes are depicted above the M. marinum sequence for members of the ancestral lineage, as indicated, and below for the classical lineage (exemplified by Agy99). Grey areas indicate differences of insertions, deletions, or InDels, as compared to M. marinum. Nomenclature of CDSs is indicated along the M. marinum annotation [40], i.e. 3970 stands for MMAR_3970. Symbol explanations see legend. Note that some genomic loci of Agy99 can neither be aligned directly to M. marinum M nor to M. ulcerans ancestral haplotypes due to major sequence rearrangements and displacements in the classical lineage only (indicated with *). Pseudogenes caused by frame shift mutations, according to the M. ulcerans Agy99 genome annotation, are marked as “x”. Bar = deletion. Blunt ends of bars: breakpoints exactly defined. Blurred ends of bars: breakpoints approximately. MURDs are confined to the M. ulcerans classical lineage but are usually not deleted in the ancestral lineage. Not shown are RDs6 and 7 since they do not reveal deletions relative to M. marinum M. A corresponding and complete list of silenced CDS is supplied in Table S1.

Figure 2

doi: https://doi.org/10.1371/journal.pntd.0000353.g002