The Effect of Azithromycin on Ivermectin Pharmacokinetics—A Population Pharmacokinetic Model Analysis
Figure 7
Upper panel: Observed maximum ivermectin concentration data in baseline and interaction arms from all subjects (open boxes) and from subpopulations A and B (shaded and hatched boxes).
Lower panel: Maximum concentration data from 1000 simulation replicates using the non-mixture model in all subjects (open boxes) and from the mixture model in subpopulations A and B (shaded and hatched boxes). The line in the interior of the box denotes the median, the bottom and top edges denote the first and third quartiles, respectively. The lines from the top and bottom edges extend to 1.5 times the interquartile range. Values exceeding the interquartile range are plotted as individual points.