Evidence of a causal relationship between body mass index and psoriasis: A mendelian randomization study
Fig 4
Reverse-direction MR analysis: Genetic liability for psoriasis upon BMI.
Meta-analysis of one-sample and two-sample MR estimates (using individual psoriasis SNPs as instrumental variables). One-sample MR was performed separately in UK Biobank and HUNT using individual-level data. Two-sample MR was performed with published GWAS sum mary-level data for BMI [14] and psoriasis [16] Estimates represent the change in BMI (kg/m2) per doubling odds of psoriasis. F-statistic = 6,415, R2 = 2.1% (UK Biobank); F-statistic = 340, R2 = 1.8% (HUNT). BMI, body mass index; CI, confidence interval; GWAS, genome-wide association study; HUNT, the Nord-Trøndelag Health Study; MR, mendelian randomization; SNP, single-nucleotide polymorphism.