Whole Blood Gene Expression Profiles to Assess Pathogenesis and Disease Severity in Infants with Respiratory Syncytial Virus Infection
Figure 4
Top canonical pathways expressed in children with RSV LRTI.
IPA showed that the interferon-signaling pathway followed by genes related to cell cycle and hematopoietic precursors (ATM) were the most upregulated pathways, while the B cell and T cell signaling pathways were the most downregulated pathways, confirming our previous results using modular-level analyses. iCOS-SL in Th cells, inducible costimulator signaling in T helper cells.