Novel Therapies for Tuberculosis: Tuberculosis Control and its Discontents

Salomon JA et al. [1] show through mathematical models the hypothetical high impact on tuberculosis (TB) control of a new shorter treatment regimen in South-East Asia. The model assumes all the positive determinants to enhance TB control but none of the negative ones, so the model is a kind of tautology that drives to an inevitable success. 
 
Defaulting, relapsing, and drug resistance do not have to be major problems when a TB control programme based on DOTS [directly observed treatment, short-course] strategy is well established with the current six months treatment [2]. These factors are usually cited as the main obstacles to control TB, the patients being the guilty party, but the reality is more complex: failed health systems, inequity, and poverty hamper the right to use TB services. 
 
It is arguable that shorter regimens and new technology increase case detection by themselves. Their effect is all the greater in an environment of health inequality and scarcity, as in the high TB burden countries. It is not clear if new drugs and technology will be cheaper, fully feasible, and more effective than the current ones on the field. 
 
Strengthening of operative health research could be the fastest way in the short term to find local solutions to use meagre financial resources [3]. Migration of local health workers looking for better living conditions could be critical for the TB programmes in the future [4]. It is likely that new tools and treatments need equal or more qualified human resources than are needed today. Lack of qualified health personnel, fast rotations in their posts, and reductions of personnel due to health sector reform policies shrink the cost effectiveness of training human resources on TB control and paradoxically could increase the necessity of more personnel for the same outcome. 
 
On the other hand, World Health Organization indicators to evaluate TB control may not be the most appropriate to measure the reality [5]. A critical revision of current measuring tools will shed light on the success and pitfalls of TB control [6]. Changes in the fashion of global disease control priorities, rise of expenses as programmes develop, and donor fatigue should be contemplated in the long term [7]. 
 
The barriers to access TB services are caused mainly by poverty and its complex socioeconomic determinants, but this key variable is hard to represent into the mathematical models [8]. Could TB be controlled through technology despite a world of increasing poverty?

Review Board (WIRB) and address the errors and misconceptions contained therein.We have worked diligently to protect the IRB decision-making process from the "forprofi t" confl ict and many believe that WIRB has set the standard for separation of board and business in the IRB community.
More than 200 people visit WIRB each year to observe our processes, systems, and board meetings.These visitors fi nd that: • The ethics review process is totally separate from the business of WIRB.• The regulations are carefully and completely respected on a daily basis.• Freedom of decision-making is expected by and of each board member.• Board members and alternates are fully trained and regularly updated.• Appropriate expertise is available.
• Disapprovals are as respected as approvals.
• There is never pressure to change a decision.• WIRB's work comes from the 148 academic and other institutions where WIRB is listed on the Federalwide Assurance form and includes both federally funded and privately funded research from non-institutionally based investigators; about one-third comes from the 400+ public companies, contract research organizations, and foundations that fund medical research.
The following inaccuracies refl ect the credibility of the referenced Bloomberg Market article: • WIRB's annual revenues were not accurately stated.
• The number of Food and Drug Administration (FDA) submission reviews attributed to WIRB was not accurate.• The Georgia investigators, whom WIRB last reviewed in 1994, were not jailed for endangering research subjects but for diverting funds from the state of Georgia.• WIRB was not the primary target of the lawsuit cited, which was settled by the insurer as a nuisance settlement on behalf of the group.• FDA's audits are not done haphazardly; they occur every three years or as indicated.
Auditors, the FDA, the Offi ce for Human Research Protections, and accreditors see our work around the world.Any fl aws surely would be noticed and corrected.WIRB will continue to rely on our longstanding reputation for transparency and reliability in the research community.

Research Ethics Boards: No Data on Quality of For-Profi t or Non-Profi t IRBs Adil E. Shamoo, Elizabeth Woeckner
We are concerned by two inaccurate statements offered by Emanuel [1].First, he claims: "And in recent years, the OHRP [Offi ce for Human Research Protections] has called upon WIRB [Western Institutional Review Board] to re-review protocols and revamp the IRB processes and procedures at not-for-profi t academic institutions where the OHRP had temporarily suspended research."We were suffi ciently surprised by this that we sought clarifi cation from OHRP Director Bernard Schwetz, who was kind enough to explain that Emanuel's statement was incorrect, and further, that "The Offi ce for Human Research Protections has never asked WIRB to re-review protocols for any institution, nor would OHRP endorse any IRB in such a manner.OHRP will provide information about the several such IRBs.However OHRP does not suggest that we endorse any of these commercial or independent IRB services" [B Schwetz, personal communication].
Accordingly it is incorrect to conclude, as Emanuel does, that "Calling upon WIRB constitutes a vote of confi dence by federal regulators that at least this one for-profi t entity provides high-quality IRB review."Second, Emanuel writes: "OHRP has never suspended a for-profi t IRB."This is misleading and incorrect in that OHRP regulates institutions, not IRBs.OHRP Director Bernard Schwetz was kind enough to clarify that "While this statement is true, it is also true that OHRP has never suspended a not-for-profi t IRB." It is useful to refl ect upon the fact that WIRB has been the IRB of record in a number of egregious cases.For example: Faruk S. Abuzzahab, MD (medical license suspended following the death of research subject inter alia); Robert A. Fiddes, MD (indicted and convicted for research fraud); and Richard L. Borison, MD and Bruce I. Diamond, PhD (indicted and convicted for research fraud) [2].Moreover WIRB was copied on the OHRP determination letters to Oregon Health and Science University regarding the Student Athlete Drug Surveillance Trial trial, the reasonable conclusion from which is that WIRB was involved in its review and approval [3,4].
There is no data, scientifi c or otherwise, because the lack of universal, legally codifi ed human research protections discourages, if not prevents, collection of such information.We agree that commercial IRBs are not unacceptable simply because they review proposed research for a fee, but commercial IRBs may provide unacceptable review and oversight when they exist primarily to provide rapid approvals.
Finally, we would like to offer bibliographical addenda.Emanuel writes: "With Wood and Grady, I have proposed a system of regional ethics organizations that would review and monitor research protocols."A recent paper reviewed the history of the proposals for regional IRBs [5].The earliest suggestion for regional ethics organizations identifi ed was Alberti (1995) [6].
Adil E. Shamoo (ashamoo@umaryland.edu)Our basic argument is this: for-profi t research ethics boards are in a client-provider relationship with study sponsors; this relationship creates a confl ict of interest; and this confl ict of interest is particularly dangerous under a weak regulatory system which does not prevent forum shopping and allows market criteria to infl uence committee selection.We use various examples of serious controversies to support our claim that there are fl aws in the system.This seems more appropriate than using one or two "good examples" to argue that the system works just fi ne.The claim by two for-profi t research ethics boards that they manage to perform admirably despite this confl ict of interest would not undermine our argument, even if independent evidence were given for the claim.(None is given here, of course.)Academic committees are certainly also affected by confl icts of interest.But that doesn't remove the confl ict in for-profi t review.The widely lauded system of accreditation is in our opinion a soft self-regulatory mechanism which does not fi ll the regulatory loopholes.
Lestou, Ondrusek, and Blajchman [1] are members of IRB Services, the for-profi t research ethics committee that approved the controversial immunosuppressant study conducted at an Anapharm research unit in Montreal.As we noted in our article, which referred to a Bloomberg report [2], a number of subjects in that trial were infected with tuberculosis.Commentators (Steven Miles, and one of us-Lemmens) interviewed by Bloomberg criticized IRB Services for some aspects of its review, including for not imposing basic tuberculosis screening of participants and for approving a backloaded payment structure intended to keep people in the trial [2].It is worth noting that Anapharm used at least one other prominent Canadian for-profi t committee in the past [3], raising concerns about forum shopping.
We referred to WIRB in our article because WIRB is frequently lauded as setting the highest research ethics standards.Thus it seems particularly relevant that even WIRB has had its share of problems.Our reference to the sheer number of reviews conducted by WIRB refl ects our concern about the power of one commercial entity in the exercise of what we consider a fundamental public function.WIRB has become a state within the state when it comes to the protection of human subjects.Particularly in the absence of strict regulatory control, it is worth asking whether it is healthy to concentrate so much power over the protection of human subjects in the hands of one commercial enterprise.
Shamoo and Woeckner [4] rightly point to the diffi culty of gaining empirical evidence on research ethics boards.One of us conducted a survey of for-profi t research ethics boards in 1997 [5].While several committees collaborated well with this survey (including WIRB and IRB Services), much information remained hidden behind a veil of corporate secrecy.Regulatory agencies in Canada and the United States simply accept this secrecy.Some regulators even rely on the goodwill of research ethics boards to determine regulatory initiatives.When the US Food and Drug Administration looked into the issue of "IRB shopping," for example, it invited comments, received them primarily from those in the industry, and simply accepted the claim that shopping for research ethics boards was not a serious concern [6].
The idea of regional committees is indeed not new, as Shamoo and Woeckner indicate.They cite as fi rst source an article of 1995.However, research ethics committees with exclusive territorial jurisdiction have existed in several European countries since the late 1980s to early 1990s (e.g., France, Switzerland, and Denmark).They have since been introduced in many more countries.Emanuel suggests that we have failed to make positive contributions to the debate on the organization of research ethics boards and contrasts that with his 2004 proposal for regional review boards.In fact, one of us (Lemmens) has argued since 1996 for improvements to the regulatory structure of research ethics boards, including the introduction of regional committees, in scholarly journals [5,[7][8][9][10][11], at international conferences, and in a report for the Council of Europe [9].Excerpts of one of these articles [7] were reprinted in a text book on research ethics edited by Emanuel and others [12].We are pleased to know that Emanuel has come to agree.
Trudo Lemmens (trudo.lemmens@utoronto.ca)University of Toronto Toronto, Ontario, Canada Royal Flemish Academy of Belgium for Science and the Arts Brussels, Belgium Carl Elliott University of Minnesota Minneapolis, Minnesota, United States of America drug companies [1] is one of several alternatives that deserve debate [2].
The Sotelo proposal has advantages, but if the CRC is a single international monopoly how could the risk of corruption and ineffi ciency be managed?Alternatively, if there were competing CRCs, they would be under pressure to compromise to win more contracts, as happens already with contract research organisations.
Fiona Godlee has proposed that pharmaceutical manufacturers be banned from researching their products [3].She suggests that "to get their products licensed [drug companies] would contribute to a central pot for independent, publicly funded clinical trials."She did not specify what percentage of the "central pot" would be funded by taxpayers versus pharmaceutical companies.If the funding was mostly from pharmaceutical companies then her proposal is similar to Sotelo's.If not, how will governments to be persuaded to allocate adequate funds?
My organisation, Healthy Skepticism Inc., advocates a more comprehensive alternative that will also reduce the harms currently caused by misleading promotion, biased industry funding of education, and high drug prices.Our alternative is politically achievable because implementation can be achieved without increasing costs for pharmaceuticals currently paid by individuals and/or third party payers (governments or insurance companies) whilst securing long-term competitive return on investment for the pharmaceutical industry.
Pharmaceutical companies currently have four main functions: manufacturing, research, promotion, and education.Performance of those functions is currently distorted by incentive systems that reward only activities that increase sales of more expensive drugs regardless of the impact on health care.We recommend that these four functions be paid for separately by government agencies via iterative open competitive public tender.This would allow the relevant divisions and subcontractors of pharmaceutical companies to compete with universities and other nonprofi t organisations for funding to provide each function separately.Incentives can then to be aligned to reward quality performance at each function separately.If a company performed poorly, e.g., committed research fraud or provided misleading promotion, then it would not get funding for that function in the next tender round.Drug prices would no longer include a premium for research, promotion, and education.Consequently, drug companies would no longer fund those functions from drug sales.Lower prices would make drugs more cost-effective for larger numbers of people.
Our recommendations can be implemented quickly or slowly by gradually reducing prices and transferring the savings to organisations that fund research (e.g., the United Kingdom Medical Research Council); education (e.g., medical schools and specialist colleges); and promotion (e.g., Best Practice Advocacy Centre, New Zealand).We also recommend improving regulation of pharmaceutical companies and improving education, incentive systems, and regulation for health professionals [4][5][6][7].

Industry-Sponsored Research: Author's Reply
In his letter [1] Dr. Mansfi eld has raised a debatable issue: "If the CRC [Collegiate Research Council] is a single international monopoly how could the risk of corruption and ineffi ciency be managed?"By no means would the CRC be an international monopoly; in the proposal it was stated that the CRC would be certifi ed by the appropriate health authorities of any country.Moreover, several CRCs could be established, as long as the participants were nominated by prestigious academic institutions and the CRC was certifi ed by the federal regulatory agencies.
The risk of corruption and ineffi ciency would be remote for the following reasons.The constituents of the CRC would be distinguished scholars, appointed independently by leading medical institutions and universities.Contrary to Dr. Mansfi eld's and Dr. Prabhakar's fears [1,2], this council would not require a substantial infrastructure, since its main goal would be to meet periodically, to select the investigators and institutions that would conduct the clinical protocol submitted during that period, and to review the results generated by previous trials.This task could be expedited through the peer review method.The administrative implementation necessary to carry out the decisions of the CRC might be done by existing institutions (e.g., the US Food and Drug Administration), without the formation of an additional bureaucratic body.In this way, the CRC would be strictly maintained as an academic and scientifi c core whose opinions and sanctions were respected by the individuals and institutions involved in the execution of any given protocol of drug testing.
The CRC would not have "bureaucratic bodies," as it would function only as a collegiate board to select who would do the testing and where a given protocol of drug testing would be conducted.The research funds provided by the pharmaceutical company would not be administered by the CRC, but by the corresponding institution in charge of the specifi c research or by the administrators appointed by the CRC.
To the question of who would fund the CRC the answer is simple: a very small percentage of the total cost of the protocol would be used to create a fund to cover travel expenses and stipends for the scholars participating in the CRC.
In response to the statement that the CRC "will consume signifi cant amounts of time and human resources" [2], I do not see why this should be the case.I believe that the members of the CRC could meet once or twice a month and propose, in a single day, one or various candidates for a given protocol.The operation of the CRC would be somewhat similar to that of the editorial board of scientifi c journals who meet periodically to select reviewers for scientifi c papers and to evaluate the results of reviews.Once the scholars of the CRC had selected the potential investigators or institutions they would be invited to conduct the research; this task could be accomplished by commissioned personnel independent from the regulatory agency.
With regard to the prices of drugs, I think that Dr. Prabhakar has not chosen a comparable example.In fact, hospital charges and physicians' consultations are not controlled in most countries; that is because these prices are usually set-very much as for many other services and goods-by production costs and competition.As mentioned in my proposal, this is not the case for pharmaceutical substances.

Profi ling of CSF: Authors' Reply
We are grateful to Dr. Matthews for his comments [1].With a sensitivity of 82% and a specifi city of 85%, the metabolic markers for schizophrenia identifi ed in our study are certainly not perfect.However, we have already identifi ed further biomarkers and envisage that a panel of biomarkers can be used for diagnostic purposes.The utility of these biomarkers will be established in our future clinical studies.
We take the point of Dr. Hambridge [2], and agree that patients who present with schizophrenia-like symptoms need to be fully investigated with respect to possible (treatable) underlying pathologies.However, we strongly disagree with the concept of schizophrenia not being an "organic disorder".Unfortunately, as Dr. Hambridge points out, this atavistic view is still portrayed in the current classifi cation systems, but we hope that by now most psychiatrists would agree that schizophrenia has a biological/organic aetiology.The concept of schizophrenia as a "functional psychosis" is a misnomer, as every function has a biological/organic basis.
As stated in our article, all patients included in our study underwent a thorough neurological and psychiatric examination.The majority of patients had cMRI scans or cCT scans (when MRI was not available at the time of admission), and a battery of blood tests including syphilis and endocrinological screening.Serum and CSF testing for neurotropic viruses and borreliosis as well as routine parameters were undertaken in accordance with European guidelines for cerebrospinal fl uid (CSF) diagnostics.
Furthermore, patients had urine drug screens, an electroencephalogram, and were examined using a neuropsychological test-battery as well as having an optional HIV test as fi rst-line investigation.For our study as well as for our daily clinical routine, the diagnosis of schizophrenia or schizophreniform disorder (with regard to time criteria only) is only given if no fi ndings indicative of other neuropsychiatric/neurological disorders, other than schizophrenia, were obtained.We would like to emphasise that it is not our opinion that the possible use of biomarker profi les, such as those identifi ed in our study, would eliminate the need for extensive neurological/biochemical screening of any patient with psychosis.Instead, our study strongly justifi es the need to perform an extensive battery of clinical tests.Unfortunately, this is not clinical practice in many countries, not least for reasons of cost and the low profi le that psychiatric patients have within our health systems.
Sabine Bahn (sb209@cam.ac.uk)The authors report that conventional antenatal corticosteroid therapy was received by all mothers [1].While antenatal steroids reduce morbidity from respiratory distress syndrome and probably reduce neonatal mortality [2], there is also evidence that the steroid has an effect on brain development [3].Multiple courses of steroids have been shown to reduce head size [4].Multiple doses of steroids are not now recommended but may have been used before 2000.How many of these mothers received multiple courses?Furthermore, if multiple courses have a demonstrable effect, it is quite feasible that there is a minor effect on the brain by a single course.
The fi ndings of this paper are consistent with capillary vascular damage occurring at delivery.73% of these babies were delivered by caesarean section.We are not suggesting that the caesarean delivery in itself would have an adverse effect, but almost certainly all these babies would have had the cord clamped immediately at delivery.Clamping the cord immediately at birth, especially before the fi rst breath is taken, interferes with the transformation from fetal to adult circulation.It is justifi ed by the need to resuscitate the baby and maintain its temperature.The intervention of immediate cord clamping needs to be justifi ed by evidence, which has never been sought.Indeed there is considerable evidence emerging that it is harmful to term [5], preterm [6], and very preterm infants [7].Immediate umbilical cord clamping is the result of tradition and is carried out without thought by the vast majority of obstetricians and paediatricians.In the 1980s Peter Dunn, working in Bristol, demonstrated a technique of delivery at caesarean section for the preterm baby which avoided the hazards of immediate cord clamping [8].This was before the use of antenatal corticosteroids or surfactant, yet the survival rates were excellent.
We would like to alert the clinical community to two issues.Firstly, antenatal corticosteroids are currently given much too readily, often when there is very little risk of preterm birth.Secondly, the cord must not be clamped immediately at delivery, especially for caesarean sections, and ways to allow resuscitation of the neonate with the cord intact must be routine clinical practice.Further research is needed to determine how much of the brain damage demonstrated in this paper could be the result of antenatal corticosteroids and immediate cord clamping.

Novel Therapies for Tuberculosis: Tuberculosis Control and its Discontents Jose Luis Portero, Maria Rubio
Salomon JA et al. [1] show through mathematical models the hypothetical high impact on tuberculosis (TB) control of a new shorter treatment regimen in South-East Asia.The model assumes all the positive determinants to enhance TB control but none of the negative ones, so the model is a kind of tautology that drives to an inevitable success.
Defaulting, relapsing, and drug resistance do not have to be major problems when a TB control programme based on DOTS [directly observed treatment, short-course] strategy is well established with the current six months treatment [2].These factors are usually cited as the main obstacles to control TB, the patients being the guilty party, but the reality is more complex: failed health systems, inequity, and poverty hamper the right to use TB services.
It is arguable that shorter regimens and new technology increase case detection by themselves.Their effect is all the greater in an environment of health inequality and scarcity, as in the high TB burden countries.It is not clear if new drugs and technology will be cheaper, fully feasible, and more effective than the current ones on the fi eld.
Strengthening of operative health research could be the fastest way in the short term to fi nd local solutions to use meagre fi nancial resources [3].Migration of local health workers looking for better living conditions could be critical for the TB programmes in the future [4].It is likely that new tools and treatments need equal or more qualifi ed human resources than are needed today.Lack of qualifi ed health personnel, fast rotations in their posts, and reductions of personnel due to health sector reform policies shrink the cost effectiveness of training human resources on TB control and paradoxically could increase the necessity of more personnel for the same outcome.
On the other hand, World Health Organization indicators to evaluate TB control may not be the most appropriate to measure the reality [5].A critical revision of current measuring tools will shed light on the success and pitfalls of TB control [6].Changes in the fashion of global disease control priorities, rise of expenses as programmes develop, and donor fatigue should be contemplated in the long term [7].
The barriers to access TB services are caused mainly by poverty and its complex socioeconomic determinants, but this key variable is hard to represent into the mathematical models [8].Could TB be controlled through technology despite a world of increasing poverty?
Jose Luis Portero (jporteronavio@yahoo.com) Maria Rubio David Hutchon (DJRHutchon@Postmaster.co.uk)Ben Ononeze Darlington Memorial Hospital Darlington, County Durham, United Kingdom Citation: Hutchon D, Ononeze B (2006) Preterm birth: Effect of corticosteroids or immediate cord clamping?PLoS Med 3(10): e462.DOI: 10.1371/journal.pmed.0030462Copyright: © 2006 Hutchon and Ononeze.This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.Funding: The authors received no specifi c funding for this article.Competing Interests: The authors have declared that no competing interests exist.DOI: 10.1371/journal.pmed.0030462 © 2006 Peter Mansfi eld.This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.The authors received no specifi c funding for this article.Peter Mansfi eld has received funding for small contracts from organizations that could benefi t from implementation of Healthy Skepticism's recommendations, including many universities, Consumers International, the Royal Australasian College of Physicians, and the National Health and Medical Research Council (Australia).