Profile of Immune Cells in Axillary Lymph Nodes Predicts Disease-Free Survival in Breast Cancer
Figure 4
DFS Analysis of Women with Breast Cancer According to Tumor Stage, T1 and T2, and Immune Profile Characteristics, Learning and Test Sets
KM curves are shown for (A) median DFS applied to the learning set (n = 29) and test set (n = 48) according to tumor stage; (B) DFS stratified by size of ALN CD4 T cell and ALN CD1a dendritic cell populations among individuals with T1 tumors; and (C) DFS stratified by size of ALN CD4 T cell and ALN CD1a dendritic cell populations among individuals with T2 tumors. Thresholds for ALN CD4 T cell and ALN CD1a dendritic cell populations were determined by receiver-operating-characteristic curves as applied to the learning set (ALN series 1). Median duration of DFS are indicated; – indicates a median DFS greater than follow-up period, 5 y. Of 77 individuals, 33 had disease recurrence. Of 41 from individuals with T1 tumors, 15 had recurrent disease. Of 33 individuals with T2 tumors, 15 had disease recurrence. For ALN selection from the learning set, a single ALN was randomly selected from series 1 or series 2 per individual. Adjusted p-values were determined by the permuted log-rank statistic for comparison of DFS between groups.