Negative linkage disequilibrium between amino acid changing variants reveals interference among deleterious mutations in the human genome
Fig 4
Results from the matched-pairs permutation test for non-African 1KGP populations.
(A) Across four other populations in the 1KGP, NS pairs of variants have lower values of D’ (i.e. have more negative LD) than their matched S counterparts. The quantile bins on the x-axis were set by combining all pairs of variants across all populations and assigning them into 5 bins based on the centimorgan distance between variants with roughly equal numbers of pairs in each bin. Thus, each population has the same centimorgan distance used to define each bin. (B) Matched-pairs permutation test shows significantly more negative average LD between pairs of NS SNPs than S SNPs in all populations except the CEU population, where this difference is not significant.