Convergent genetic aberrations in murine and human T lineage acute lymphoblastic leukemias
Fig 2
Somatic alterations are frequently predicted to be pathogenic and correspond to mutations in human T-ALL.
(A) Notch1, Pten, Raf1, and Trp53 mutations in IM-induced T-ALLs (top panels) occur within hotspot locations that correspond to recurrent mutations in human cancer (bottom panels). (B) In silico protein function prediction indicates that mutations highlighted in Fig 1 are frequently deleterious and occur at residues that are conserved across multiple species.