MAPK and GSK3/ß-TRCP-mediated degradation of the maternal Ets domain transcriptional repressor Yan/Tel controls the spatial expression of nodal in the sea urchin embryo
Fig 3
Yan/Tel is required before Lefty to restrict nodal expression and acts redundantly with FoxQ2 in the animal pole region.
A, Time-course of nodal expression in control, lefty morpholino and yan/tel morpholino injected embryos. Note that ectopic expression of nodal is detected in the yan/tel morphants earlier than in the lefty morphants. (EB), early blastula; (PHB), pre-hatching blastula. B, Note that nodal is ectopically expressed in the animal pole region (asterisks) of embryos co-injected with foxQ2 and tel or panda morpholinos, but absent from this region after co-injection of the lefty and panda or yan/tel morpholinos. All views are lateral. Animal is to the top, and ventral to the left.