Tandem duplications lead to novel expression patterns through exon shuffling in Drosophila yakuba
Fig 4
Tandem duplication creates a de novo gene on chromosome 3R.
The 5′ end of GE24349 is duplicated and placed adjacent to formerly untranscribed sequence, producing transcription and putative de novo gene creation. The reference strain does not show transcription in the region (grey) and no other sample strain exhibits upregulated sequence across the region. Sites with upregulated or downregulated sequence as defined by HMM output is shown in blue, using the right axis. HMM state calls for sites with unchanged expression are not shown. The region spanned by the tandem duplication is shaded in grey. The tandem duplication activates a previously untranscribed region from roughly 14703500–14705000 bp. There is also upregulation in some exons for GE24349, possibly indicating a longer fusion transcript that reads through to the end of the nearest adjacent 3′ UTR.