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A Shh-Foxf-Fgf18-Shh Molecular Circuit Regulating Palate Development

Fig 4

Differential gene expression analysis of palatal mesenchyme cell in control and Foxf2 mutant embryos by using RNAseq and real time RT-PCR assays.

(A, B) The patterns of RFP expression in the Osr2^RFP/+ (A) and Foxf2^-/-Osr2^RFP/+ (B) palatal shelves are comparable. White dashes demarcate the palatal shelf on the right side. (C) Real time RT-PCR analysis of the levels of expression of Foxf2, Osr2, Fgf18, Shox2, Barx1, and Ptch1 mRNAs in E13.5 palatal mesenchyme cells in control and Foxf2^-/-Osr2^RFP/+ embryos (**p<0.01, ***p<0.001).

doi: https://doi.org/10.1371/journal.pgen.1005769.g004