A System for Genome-Wide Histone Variant Dynamics In ES Cells Reveals Dynamic MacroH2A2 Replacement at Promoters
Figure 5
Promoter MacroH2A2 dynamics correlate with transcription.
(A) Genes from Cluster 1 are sorted by the change in Macro enrichment from 3 to 12 hours (change in Macro is schematized in green to red colorbar to the left). (B) 80 gene running window average of mRNA abundance [42], expressed as log2 of the Affymetrix microarray probe intensity, for genes sorted as in (A). r = 0.46 between turnover (expressed as log2 t = 3/t = 12) and mRNA abundance. (C–D) Genome browser tracks for one “hot” and one “cold” example gene, as indicated in (A).