Sp6 and Sp8 Transcription Factors Control AER Formation and Dorsal-Ventral Patterning in Limb Development
Figure 10
Regulatory pathways mediated by Sp6 and Sp8.
Sp6 and Sp8 are necessary mediators of the Wnt/βcatenin-dependent induction of Fgf8 in the limb ectoderm. In addition, these two factors also collaborate with BMP signaling in the induction of En1 in the ventral limb ectoderm. Finally, Sp6 and Sp8 may also act downstream of Tp63 and Dlx genes.