Evolutionarily Diverged Regulation of X-chromosomal Genes as a Primal Event in Mouse Reproductive Isolation
Figure 3
Differential expression of MSM-derived genes in B6-ChrXTMSM testes.
(A) Gene expression on control chromosome 3 and the X chromosome in B6-ChrXTMSM testes. Vertical dotted line in the bottom panels indicates the boundary of recombination. The MSM-derived region is distal to the boundary. Note that the variance of fold change in the MSM-derived region was larger than that in the other chromosomal region. Transcripts in red showed a significantly different expression level by the Benjamini-Hochberg FDR corrected moderate t-test (P<0.05; fold change ≥1.50). (B) Frequency of upregulated and downregulated transcripts for each chromosome in B6-ChrXTMSM testes. Chromosomes are indicated below the graphs. Xp and Xd represent B6-derived proximal and MSM-derived distal regions on the X chromosome, respectively. Significant enrichment of differentially expressed transcripts was observed in the distal X-chromosomal region. Differential expression was predominately genome wide at 7 dpp. (C) Venn diagram of differentially expressed transcripts in B6-ChrXMSM and B6-ChrXTMSM testes at 7 dpp. A large proportion of differentially expressed transcripts were common in B6-ChrXMSM and B6-ChrXTMSM samples. (D) Genome location of the common differentially expressed transcripts.