Determining the Control Circuitry of Redox Metabolism at the Genome-Scale
Figure 3
Integration of ChIP-chip, gene expression, and biological context.
Specific regulation of each gene product by ArcA or Fnr under strictly anaerobic and nitrate respiratory conditions are shown as columns. Each box is the result of integration between ChIP-chip and gene expression data in which a TF binding peak was identified and gene expression microarrays showed differential expression upon knockout of the transcription factor in matched conditions. The genes are grouped biologically according to the principal dimensions described in figure 2. Immediate broad trends that emerge are catabolic repression by ArcA and chemiosmotic and anabolic activation by Fnr.