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X Chromosome Control of Meiotic Chromosome Synapsis in Mouse Inter-Subspecific Hybrids

Figure 7

The proposed sequence of events leading to male limited sterility of intersubspecific hybrids of house mouse.

Susceptibility of heterosubspecific homologs to asynapsis is common to both sexes. Prdm9/Hst1 and Hstx2 hybrid sterility genes can modulate this sensitivity from 0% to >95% in spermatogenesis but not in oogenesis, depending on allelic combinations of epistatic DMIs. Multiple asynaptic autosomes provoke MSCI, contributing to hybrid male sterility. Approximately one half of unaffected oocytes ensure fertility of hybrid females. It remains to be established what is the cause of asynapsis of heterosubspecific homologs.

Figure 7

doi: https://doi.org/10.1371/journal.pgen.1004088.g007