NTRK3 Is a Potential Tumor Suppressor Gene Commonly Inactivated by Epigenetic Mechanisms in Colorectal Cancer
Figure 7
Knock-down of Ntrk3 expression contributes to neoplastic transformation in normal colon epithelial cells.
A. Ntrk3 mRNA expression was efficiently knocked down by 3 different shRNA constructs (309053, 35392 and 189598) in the immortalized mouse colon epithelial cell line, YAMC. B. Suppression of Ntrk3 promotes soft agar colony formation in the YAMC cells. The non-silencing control (NSC) is a control short-hairpin construct for the knockdown experiments. The asterisks indicate statistically significant differences. (p<0.05; two-sided student t test).