Tethering of the Conserved piggyBac Transposase Fusion Protein CSB-PGBD3 to Chromosomal AP-1 Proteins Regulates Expression of Nearby Genes in Humans
Figure 6
The CSB-PGBD3 fusion protein binds preferentially to the 5′ palindromic sequence of all bound MER85s in the human genome.
Paired-end sequence reads near bound MER85s were used to reconstruct the location of immunoprecipitated fragments relative to the 5′ target site duplication (TSD) of each element. Cumulative fragment overlaps were calculated by summing the number of fragments from each element that overlapped each position relative to the 5′ TSD. TIR, Inverted Terminal Repeat.