A Likelihood-Based Framework for Variant Calling and De Novo Mutation Detection in Families
Table 1
Percentage of missing non-reference genotypes (i.e. false negatives) per individual in families for variants called by joint modeling family data and the standard approach of ignoring relatedness for sequencing coverage between 5× and 30× and for input sequence data with Phred-scaled quality of 20 (error rate of 1% per base) or 30 (error rate of 0.1% per base) without mapping error.