Transcriptional Control in Cardiac Progenitors: Tbx1 Interacts with the BAF Chromatin Remodeling Complex and Regulates Wnt5a
Figure 3
Tbx1−/−;Wnt5a−/− embryos have severe cardiac abnormalities.
(A–D′) Whole mount histology study showed reduced overall size of Tbx1−/−; Wnt5a−/− embryos at E9.5 (n = 10), compared with control (WT), Tbx1−/− or Wnt5a−/− littermates. (A″–D″) Sagittal sections of these embryos revealed severe hypoplasia of the OFT and the right ventricle (RV) in the Tbx1−/−; Wnt5a−/− embryos. Scale bars: 100 µm.