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An Alpha-Catulin Homologue Controls Neuromuscular Function through Localization of the Dystrophin Complex and BK Channels in Caenorhabditis elegans

Figure 4

ctn-1 mutation impairs normal localization of SLO-1 in muscles and neurons.

The same integrated array, SLO-1::GFP, was used for this analysis in different genetic backgrounds. (A–B) Muscular localization of SLO-1::GFP in wild-type, dys-1 and ctn-1 animals. Arrowheads represent the ventral (or dorsal) nerve cords. (B) The graph showing quantification of puncta intensities. Error bars, s.e.m. Wild-type vs. dys-1 or ctn-1 (P<0.0001). Scale bar, 10 µm. (C–D) Neuronal localization of SLO-1::GFP in wild-type, dys-1 and ctn-1 animals (See also Figure S2). Regions of the ventral nerve cord (dashed boxes) are enlarged in the bottom left of each panel to show detail. (D) The graph showing quantification of puncta intensities. Error bars, s.e.m. Wild-type vs. dys-1 (P>0.05), Wild-type vs. ctn-1 (P<0.0001). Scale bar, 10 µm.

Figure 4

doi: https://doi.org/10.1371/journal.pgen.1001077.g004