The Mating Type Locus (MAT) and Sexual Reproduction of Cryptococcus heveanensis: Insights into the Evolution of Sex and Sex-Determining Chromosomal Regions in Fungi
Figure 6
Sxi1 and Sxi2 from C. heveanensis align with HD1 and HD2 homeodomain proteins, respectively.
(A) Alignment of the homeodomain regions of S. cerevisiae (Sc), C. cinerea (Cc), C. neoformans var. neoformans (Cnn), C. neoformans var. grubii (Cng), C. gattii (Cg), C. heveanensis (Ch) homeodomain proteins. These proteins are classified as either HD1 or HD2 according to the length of the homeodomain region. There are three extra amino acids between helix 1 and helix 2 of HD1 proteins. C. heveanensis Sxi1 and Sxi2 proteins are of type HD1 and HD2, respectively. (B) Schematic representation of the Sxi1 and Sxi2 domain structures. DD, HD, and NLS denote dimerization domain, homeodomain, and nuclear localization signal, respectively. The types of nuclear localization signal are indicated in parentheses: Bipartite and pat7, pat7 denotes the 7-residue pattern.