Genetic and Functional Dissection of HTRA1 and LOC387715 in Age-Related Macular Degeneration
Figure 2
The haplotype block in D' of rs2736911, rs10490924, in/del/Wt, and rs11200638 in the Utah case-control cohort.
The risk haplotype C-T-in/del-A is strongly associated with advanced AMD (P = 4.05×10−28); the non-risk haplotype T-G-Wt-G is significantly associated with protection of advanced AMD (P = 4.00×10−4). In/del and Wt refers to presence or absence of 54 base pair insertion and 443 base pair deletion, while the letters G, T, A refer to nucleotides for the respective SNPs at rs2736911, rs10490924, and rs11200638.