Modeling of Environmental Effects in Genome-Wide Association Studies Identifies SLC2A2 and HP as Novel Loci Influencing Serum Cholesterol Levels
Figure 2
Manhattan plot of genome-wide effects on LDL cholesterol levels in the Swedish discovery cohort.
Results for two GWAS analysis models are presented. The unadjusted model (dark blue and light blue circles) included only sex and age as covariates. The adjusted model (red and orange squares) additionally contained food intake and physical activity as predictors. The dashed line indicates the local Bonferroni-adjusted α error = 1.6×10−7.