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The Impact of Recombination on Nucleotide Substitutions in the Human Genome

Figure 3

Correlations between substitution rates and the current GC content in human autosomes.

Each dot corresponds to a 1 Mb-long genomic region. Substitution rates: number of substitutions per site in the human lineage since the divergence from chimpanzee. (A) Total substitution rate. (B–D) Base-specific substitution rates: (B) CpG G:C→A:T transition rate. (C) non-CpG S→W and W→W substitution rates. (D) W→S and S→S substitution rates. Regression lines and Pearson's correlation R2 are indicated.

Figure 3

doi: https://doi.org/10.1371/journal.pgen.1000071.g003