AGEMAP: A Gene Expression Database for Aging in Mice
Figure 4
Common Age Regulation in Human, Mice, Flies, and Worms
(A) Comparison of age-related expression changes for 2,578 orthologous genes in humans, mice, flies, and worms. Rows correspond to genes, arranged from the genes showing the greatest decrease in expression with age in both human and mouse at top to the genes showing the greatest increase in expression with age in both human and mouse at bottom. Columns correspond to tissues; tissue names are colored to denote their species of origin, either human (red) or mouse (black). Scale corresponds to the slope of the change in log2 expression with age (β1j).
(B) Comparison of age-related expression changes for 280 gene sets in humans, mice, flies, and worms. First row is the mitochondrial electron transport chain gene set, which was found to be age regulated in flies and worms in addition to mammals. Second row is the lysosome gene set, which was found to be age regulated in flies in addition to mammals. Other rows correspond to gene groups that are commonly age related in humans and mice alone. Scale refers to a Van der Waerden Z-score. Columns correspond to tissues; tissue names are colored to denote their species of origin, either human (red) or mouse (black). A navigable version of this figure exists at http://cmgm.stanford.edu/~kimlab/aging_mouse.