A Transcriptional Program Mediating Entry into Cellular Quiescence
Figure 4
SALL2 and MXI1 Are Differentially Required for Gene Regulation in SD
On the right, altered global transcriptional programs are shown 16 h after SD by transfection with siSALL2 or siMXI1, each compared against siGFP reference RNA and performed in duplicates. Red indicates higher expression in cells treated with siSALL2 or siMXI1 compared to cells treated with siGFP; green indicates the lower expression in siSALL2 or siMXI1 samples versus siGFP.
On the left, the temporal expression program of the same genes SS and SD is shown. The genes are grouped by their similarity of expression by hierarchical clustering; the three clusters indicated on the far left are as described in the text.