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Retrotransposon Silencing by DNA Methylation Can Drive Mammalian Genomic Imprinting

Figure 1

Comparison of the Genomic sStructures between SGCE and PPP1R9A, and Chromosomal Location for Tammar PEG10

(A) The green bars on the horizontal lines indicate the exons of each gene. Orthologous exons are connected between species by the broken lines. The grey bars on the upper side of the horizontal lines represent LINEs and SINEs, and the blue bars on the underside represent LTR elements. The arrowheads indicate the direction of transcription. The published opossum genome sequence used was PEG10 downstream, and was combined with our tammar genome sequence at the homologous point in the 3′ UTR of PEG10.

(B) Fluorescence in situ hybridization of PEG10 was localized to Chromosome 3q. There is a nucleus of another cell in the lower left.

Figure 1

doi: https://doi.org/10.1371/journal.pgen.0030055.g001