Adaptive Stress Response in Segmental Progeria Resembles Long-Lived Dwarfism and Calorie Restriction in Mice
Figure 1
Compound Heterozygosity at the Xpd Locus Partially Rescues Severe Progeroid NER Syndrome
(A) Growth curves of individual CH/XPA and control XPA animals from a representative litter.
(B) Food intake of CH/XPA animals versus XPA littermate controls (42 d old) and 25-d-old controls expressed per gram body weight. Asterisks indicate statistical significance (p < 0.001) versus 42-d-old controls; error bars indicate standard error of the mean (SEM).
(C) Photographs of male littermate CH/XPA and control XPA mice over 5.5 mo.
(D) Kaplan-Meier survival curve of CH/XPA and littermate control XPA mice.