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Multiscale modelling of desquamation in the interfollicular epidermis

Fig 5

Tissue structure and thickness results for different levels of inhibitor.

(A) Simulation output from one simulation (with no inhibitor) at one time point, showing the level of adhesion protein s in each cell. Note, there is no apparent difference in system dynamics compared to the normal system, just an increased rate of reduced s in time and consequently seen in the vertical direction in the image. A video of this simulation is provided in S2 Video. (B) The steady state thickness values. The points show the mean and the bars indicate the minimum and maximum thickness over the 10 realisations of each setup. The dashed line is a linear fit to the points, with the equation given in the lower right. (C) and (D) Abnormal tissue s and e levels with different levels of inhibitor. The data is taken from the final time point of one simulation for each inhibitor concentration. The dashed lines show the steady state heights for iT = 0 (black) and iT = eT (blue or red).

Fig 5

doi: https://doi.org/10.1371/journal.pcbi.1010368.g005