Skip to main content
Advertisement

< Back to Article

Injury-related cell death and proteoglycan loss in articular cartilage: Numerical model combining necrosis, reactive oxygen species, and inflammatory cytokines

Fig 8

Simulated decrease of cytokine concentration in the combined model.

(A) Simulated time-dependent exponential decrease of the interleukin-1 concentration in the culture medium and B) comparison of changes in proteoglycan (PG) content with constant (μ = 0 ) and fast-decreasing cytokine concentration (μ = 5.8×10−6 ). C) Temporal changes in cell viability in 30-day simulation near the cartilage lesion (within 0.1 mm from the lesion) and D) spatial changes at day 5. D) Temporal changes in the PG content near the cartilage lesion and (F) spatial changes in the whole cartilage geometry (total) at day 5. Decreased exogenous cytokine concentration decreased cell death and PG loss substantially and (G) showed partial recovery of the PG content (here, simulation continued until day 30). Red line in the figure refers to the reference model (decay rate of interleukin-1 concentration μ = 0 ).

Fig 8

doi: https://doi.org/10.1371/journal.pcbi.1010337.g008