Chemotherapy-induced cachexia and model-informed dosing to preserve lean mass in cancer treatment
Fig 2
Model simulation of plasma and tissue concentrations of 5-FU given (A) one dose, (B) a sequence of 28 daily doses, and (D) a sequence of 20 doses following the (5-on, 2-off) schedule.
The dose of 35 mg/kg was simulated by numerically solving Eqs (1) and (2). The 5-day average exposure for (C) the daily schedule and (E) the (5-on, 2-off) schedule was computed from Eq (9) for τ = 5.