Numerical approaches for the rapid analysis of prophylactic efficacy against HIV with arbitrary drug-dosing schemes
Fig 6
Long-term prophylactic profile with different levels of adherence.
N = 1000 virtual patients were sampled from the pharmacokinetic parameter distributions defined in Table 2 of [11]. 50 mg dose of DTG / day was ingested in this six-month-long regimen with adherence level of 0.75, 0.5, 0.33 and 0.25. The red line depicts the median predicted prophylactic efficacy, whereas the dark- and light grey areas present the quartile range and the 2.5%–97.5% range respectively. The prophylactic efficacy was computed for Y0 = [1, 0, 0]T.