Bridging cell-scale simulations and radiologic images to explain short-time intratumoral oxygen fluctuations
Fig 5
Robustness of optimal influx and uptake schedules.
A. Parameter spaces of all tissues with oxygen levels within +/- 3.5 mmHg of the maximum experimental value for each ROI; 3D convex hulls shown in cyan, together with convex hulls for optimal influx schedule (green) and optimal uptake schedule (black) that fit experimental data with normalized L2-norm smaller than 0.2. B. Normalized L2-norms for influx schedule (green dots) and uptake schedule (grey dots) for each tissue from the cyan convex hull. The red dashed line represents the L2-norm value of 0.2. The results are shown from left to right for: ROI#1 (black), ROI#2 (red), ROI#3 (blue), and ROI#4 (magenta).