Chromosomal neighbourhoods allow identification of organ specific changes in gene expression
Fig 4
Only tooth developmental genes are differentially expressed within 1 Mb windows in the developing mouse molar.
Median expression levels of the tooth developmental genes Ctnna1, Shh, Foxi3 and Sostdc1 and their neighbouring genes at developmental stages E13 and E14. Regardless of their expression level, the surrounding genes show little change between the two stages whereas the tooth genes are upregulated. Egr1 in the 1 Mb window of Ctnna1 is also a tooth developmental gene.