Public Baseline and shared response structures support the theory of antibody repertoire functional commonality
Fig 3
(A) Alignment of the solved Ustekinumab crystal structure (3hmw) and the closest Public Baseline AML structure (H14012+L14649). (B) Comparison of the Ustekinumab Fv sequence and a Gidoni et al. naïve Fv sequence assigned by Repertoire Structural Profiling to the H14012+L14649 Public Baseline structure. The North-defined CDR regions of each chain are highlighted in bold. (C) An alternative VL sequence coupled to the same Gidoni VH sequence. This sequence has a more sequence similar CDRL3 but a less similar CDRL2.