Predicting kinase inhibitors using bioactivity matrix derived informer sets
Fig 1
IBR (Informer-Based Ranking) for compound prioritization on a novel target.
From a complete bioactivity data matrix (blue grid), a subset of informer compounds (green stars) are identified from the broader set of compounds (stars) that have been tested against a large set of targets (pink circles). A previously uncharacterized target (red circle) is assayed with just the informer compounds, and the new bioactivity data are used to reveal the new target’s relationship to other targets. The combined data enable activity predictions (purple) on the remaining, non-informer compounds.