Neuronal gain modulability is determined by dendritic morphology: A computational optogenetic study
Fig 6
Partial and graded illumination in L5PC.
(A) Partial illumination in L5PC model, where the apical but not the basal dendrites are illuminated; (B) The resulting IF curve for partial illumination shows no gain modulation for same input as used in Fig 2D, where full illumination showed strong gain modulation; (C) Graded illumination over L5PC, from superficial layer at apical dendrites; (D,E) Graded illumination for fixed xNpHR and irradiance, for different combinations of graded illumination. For both axis zero represents no grading (i.e. uniform irradiation of complete apical tree), and one represents maximum grading which goes from the nominal irradiation at the top to zero irradiation at the bottom. The responses for no graded illumination (purple circles) are moderately reduced when ChR2 is scattered slightly more than NpHR (blue circles), and nearly abolished when ChR2 is scattered significantly more than NpHR (green circles).