Spatial organization of the budding yeast genome in the cell nucleus and identification of specific chromatin interactions from multi-chromosome constrained chromatin model
Fig 4
Interactions among fragile sites and their distribution in the budding yeast genome.
(A) Mean interaction frequency between fragile sites (shown as thick green line) and the histogram of mean interaction frequencies between 10,000 sets of 95 random sites. (B) The distribution of fragile sites in the 16 chromosomes. (C) Heat map of interaction frequencies between fragile sites as computed from the fully-constrained ensemble. The length of each chromosome is proportional to the number of fragile sites it contains. All high frequency interactions (red) are predicted to occur between different chromosomes, except those on the diagonal. (D) The distribution of fragile sites by their genomic distances to the corresponding centromeres.