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A data-driven modeling approach to identify disease-specific multi-organ networks driving physiological dysregulation

Fig 8

Autonomic dysfunction-specific single nucleotide variants in regulatory regions upstream of prominent genes.

(A) Example spatial relations amongst an SNV, TFBS, and transcription start site. (B) Transcription factor binding motif associated with Tfap2a along with the respective sequences in the autonomic dysfunction and control phenotypes. A single nucleotide variation (SNV) occurs in a key element of the putative binding site for the autonomic dysfunction phenotype. (C) Summary of TFs with bioinformatically identified TFBSs in or near autonomic dysfunction-specific SNVs upstream and proximal to genes implicated in physiological homeostasis.

Fig 8

doi: https://doi.org/10.1371/journal.pcbi.1005627.g008