A Network Model of Local Field Potential Activity in Essential Tremor and the Impact of Deep Brain Stimulation
Fig 1
Schematic representation of the network modelled in the study.
(A) The model contains four populations, the motor cortex, the Vim nucleus of the thalamus, the reticular nucleus of the thalamus (nRT) and the deep cerebellar nuclei (DCN). In addition, there are two additional inputs, a constant external input in through the cerebellar population and the DBS input into the Vim. (B) The DBS input, unlike the external input, is not tonic, but oscillatory over time. We used a biphasic square pulse to mirror the pulses used in clinical therapy. The waveform is defined by the following parameters: frequency (f), amplitude (A), pulse width (PW) and the multiple for the biphasic phase (m).