Molecular Dynamics of "Fuzzy" Transcriptional Activator-Coactivator Interactions
Fig 1
Transcriptional activation via the Mediator complex.
The schematic diagram shows the gene-specific transcription factor GCN4 bound sequence-specifically to a target site ("Upstream Activation Site"; "UAS"). The basal transcriptional machinery (including RNA polymerase II [RNAPII]; basal transcription factors TFIIB, TFIID, TFIIE, TFIIF and TFIIH; the multi-subunit "Mediator Complex") assembles around the transcription start site indicated by an arrow. The GAL11 subunit of the Mediator is specifically identified. The regulatory protein-protein interaction of the GCN4-activation domain (cAD) with GAL11 is represented by a two-headed arrow.