Inferring Regulatory Networks from Experimental Morphological Phenotypes: A Computational Method Reverse-Engineers Planarian Regeneration
Fig 8
Inferred comprehensive model of planarian head-versus-tail regeneration.
(A) Regulatory network found by the automated system, which explains the combined phenotypic experimental data of the key publications of head-trunk-tail planarian regeneration. (B) Simulation of the 16 experiments comprising the dataset, resulting in the same reported experimental phenotypes. (C) Evolution of the error and complexity (number of products and regulations) of the best regulatory network in the population over time during the algorithm search.